G protein-coupled receptors: mutations and endocrine diseases
G proteins and G-protein-coupled receptors (GPCRs) mediate the effects of a number of hormones. Genes that encode these molecules are subject to loss-of function or gain-of-function mutations that result in endocrine disorders.2006年12月1日
作者：G VassartOver the past 20 years, naturally occurring mutations that affect G protein-coupled receptors (GPCRs) have been identified, ... 2011 被引用次数：132 —
作者：G VassartG protein-coupled receptors (GPCRs) are key factors in endocrinology; studies of loss-of-function or gain-of-function mutations have ... 2011 被引用次数：132 —
Mutations in G Proteins and G Protein-Coupled. Receptors in Endocrine Disease. ALLEN M. SPIEGEL. Metabolic Diseases Branch, National Institute of Diabetes ...
作者：G Vassart... naturally occurring mutations that affect G protein-coupled receptors (GPCRs) have been identified, mainly in patients with endocrine diseases. 2011 被引用次数：132 —
作者：AM SpiegelG protein-coupled receptors (GPCRs) have been identified in human diseases. Loss-of- function mutations in GPCRs for various hormones lead to hormone ... 2007 被引用次数：11 —
G protein-coupled receptors (GPCRs) are key factors in endocrinology; studies of loss-of-function or gain-of-function mutations have contributed to our ...
作者：LR MontenegroThe abnormal transduction may be due to mutations in the genes encoding either G protein-coupled receptors or G proteins or effectors. In Table 2 human diseases ... 2012 被引用次数：14 —
作者：AM SpiegelUnderstanding the molecular basis of these diseases pro- vides valuable insights into G protein and GPCR structure and function, and may be important for ... 1996 被引用次数：194 —
作者：A SpiegelPart of the Research and Perspectives in Endocrine Interactions book series (RPEI) ... In general, diseases caused by GPCR loss-of-function mutations are ... 2006 被引用次数：2 —