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OLT1177 filetype:PDF
of OLT1177, a beta-sulfonyl nitrile molecule which is safe and orally bioavailable in humans. Methods and Results: ➢ Human monocytes-derived macrophages ...
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作者:C Marchetti2018被引用次数:164 — OLT1177 reduces IL-1β but not TNFα following NLRP3 inflammasome activation. (A) OLT1177 structure. (B) Mean ± SEM percent change (range 270 to.
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作者:C Marchetti2018被引用次数:66 — Plasma OLT1177 levels correlated (p < 0.001) dose-dependently with reduction in joint inflammation. Treatment of mice with OLT1177 limited MSU crystal articular ...
Dapansutrile (OLT1177). Evidence Summary. NLRP3 inflammasome inhibitor with oral bioavailability and good short-term safety. It reduces IL-1β.
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作者:A Litwiniuk2021 — OLT1177 should be further explored in a clinical study in subjects with AD. The role of PYD-only protein (POP)1 and POP2 in the inhibition of ...
(2019) OLT1177 (Dapansutrile), a. Selective NLRP3 Inflammasome. Inhibitor, Ameliorates Experimental. Autoimmune Encephalomyelitis. Pathogenesis. Front.
The synthetic and human safe compound OLT1177 reduces inflammation by blocking the NLRP3 inflammasome. Carlo Marchetti1, Benjamin Swartzwelter1, ...
作者:Y Yang2019被引用次数:369 — OLT1177 on NLRP3 inflammasome activation and related diseases103. ... Like CY-09, OLT1177 exerts its anti-inflammatory effect.
OLT1177. ALTERNATE NAME: Dapansutrile. 3-(methylsulfonyl)-propanenitrile. CATALOG #:. B2358-25. B2358-5. AMOUNT: STRUCTURE: 25 mg. 5 mg. MOLECULAR FORMULA:.
作者:TL Jansen2019被引用次数:11 — OLT1177™ inhibits joint inflammation in humans with gout flares. Methods 29 patients with a gout flare were treated within 4.

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